Italy vs Uruguay 2023 Rugby World Cup Predictions, Odds, Picks and Betting Preview

• Italy recorded an emphatic 52-8 win over Namibia in their 2023 Rugby World Cup opener
• Uruguay lost 27-12 to host nation France in their opening game of this year's tournament
• The Azzurri are favourites to pick up the win over Uruguay in their second World Cup game

Italy will look to continue their winning ways as they prepare for their second match at the 2023 Rugby World Cup.

The Azzurri will lock horns with Uruguay and they are favourites to score a big victory over the South American side.

Read on as Sports Brief brings you a preview of this Pool A clash.

Italy vs. Uruguay Betting Preview

Where: Stade de Nice, France

When: Wednesday, September 20 - 5:45pm local time

Odds: Italy (-21.5) vs. Uruguay (+21.5); total: 49.5 - view all lines

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Betting on Italy (-21.5)

Italy will head to their showdown against Uruguay with momentum on their side after beating Namibia 52-8 in their opening group match.

The Azzurri recorded their best-ever win against the Africans with a bonus-point winning start to their 2023 Rugby World Cup campaign.

Italy have made only four changes to the side that won against Namibia, bringing in Niccolo Cannone, Marco Riccioni, Lorenzo Pani, and Alessandro Garbisi to replace Dino Lamb, Simone Ferrari, Luca Morisi, and Stephen Varney, per Flashscore.

Coach Kieran Crowley's first win as Italy's boss came against Uruguay in November 2021.

Seven players from that winning side will make the start against Los Teros on Wednesday, namely Federico Ruzza, Danilo Fischetti, Negri, Ignacio Brex, Monty Ioane, Paolo Garbisi, and captain Michele Lamaro.

Betting on Uruguay (+21.5)

Uruguay showed the world they can hang with the big boys, holding host nation France to 27 points in their opening group match earlier this month.

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The South Americans pushed the Frenchmen to the limit as they started their campaign with their best-ever result against a tier-one nation at the Rugby World Cup, per the BBC.

Nicolas Freitas and Baltazar Amaya scored the tries for Uruguay in the 27-12 loss.

Coach Esteban Meneses also liked what he saw from that performance. He made just two changes to their starting line-up for the game against Italy, inserting German Kessler and Gaston Mieres.

Writer's Prediction

Italy (-21.5) win and cover the spread.

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France vs Namibia 2023 Rugby World Cup Predictions, Odds, Picks and Betting Preview

Sports Brief takes a look at all you need to know about hosts, France taking on Namibia.

This Pool A showdown has Namibia fighting for their lives as they were defeated in their opening two games of the tournament.

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Will Les Bleu build on their average of winning a game by 14.5 points as in their first two group games?

Springboks set new World Cup record

Sports Brief previously reported on South Africa's 76-0 win over Romania.

The Springboks scored four tries in 12 minutes to set a World Cup record.

Cobus Reinach and Makazole Mapimpi both scored hat-tricks in SA's rout.