England defender Reece James will miss the Euro 2024 qualifier against Ukraine, it was announced Saturday.
The 23-year-old Chelsea right-back's season has been blighted by injury, with James missing the World Cup in Qatar due to a knee problem.
He came off the bench as 10-man England completed a 2-1 victory against reigning champions Italy in Thursday's European qualification opener -- his first cap since September.
But he has now been ruled out of Sunday's Group C match at home to Ukraine.
"Reece James has withdrawn from the England squad and will not feature against Ukraine on Sunday," a Football Association statement read.
"The full-back has returned to Chelsea for assessment on an ongoing issue."
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James follows Marcus Rashford, Mason Mount and Nick Pope in withdrawing from manager Gareth Southgate's initial squad, with the FA adding Saturday that "no replacements are planned".