Atletico Madrid and Sevilla have cut ground on Spain's traditional giants Real Madrid and Barcelona in recent years, but the tide is turning again.
In 2014 and 2021 Atletico lifted the title, while Sevilla have been in contention too, finishing in the top four in each of the last three campaigns.
However Diego Simeone's Rojiblancos visit the Ramon Sanchez-Pizjuan on Saturday looking for a vital win to try and keep a grasp on the league frontrunners' coattails, while Julen Lopetegui's side are scrambling for points to move away from the relegation zone. Loftier ambitions will have to wait.
The Andalusians have endured a torrid start to the campaign, with just one win from six games leaving them a point clear of the drop zone and piling pressure on Lopetegui.
On the sidelines of his team's 1-1 draw with Villarreal before the international break the former Spain and Real Madrid manager paced anxiously, tersely barking instructions as his team almost caved in the final stages.
To make matters worse, Lopetegui will be sweating on the fitness of playmaker Isco and midfield battler Joan Jordan, while Tecatito Corona and Marcao are poised to miss the game.
Exciting feature: Check out news exactly for YOU ➡️ find "Recommended for you" block and enjoy!
"There were many changes (in the summer), players who came in late, without a pre-season, these are things that impact performance a lot," Isco told Muchodeporte.
"(Lopetegui) is a coach who has always believed in me, I thank him for it. He's a coach who I believe in personally and the dressing room is with him. We are together, not just in the wins but also in the defeats, that's when you see a true team."
Visitors Atletico, seventh, arrive with pressure on them to make amends too, following their 2-1 home defeat by rivals Real Madrid in the derby.
That match was stained by racism from some Atletico supporters aimed at Vinicius Junior, leaving the club with work to do both on and off the pitch.
Simeone's side were also beaten in the Champions League by Bayer Leverkusen and aim to avoid a third consecutive defeat.
The game seems destined to be tight, tense, and potentially explosive as only victory will suffice for either team. Should Atletico fail to win, they could find themselves potentially 11 points behind league leaders Real Madrid.
"We'll keep working and looking at the Sevilla game, knowing that we have to improve and we will do that," pledged Simeone after the derby defeat.
With heavyweights Real and Barcelona hitting form, some in Spain wonder whether this season will be a throwback to the days of the duo racing to reach 100 points, leaving the others in the dust.
Atletico will be aiming to prove otherwise, while a victory for Sevilla could be the catalyst their season needs.
Player to watch: Karim Benzema
Real Madrid striker Karim Benzema has trained this week after injury and is expected to return against Osasuna on Sunday.
The French forward picked up his trophy for finishing as last season's top scorer in La Liga on Wednesday, but this year will be harder.
Barcelona's Robert Lewandowski leads the scoring charts on eight goals, and for now Benzema only has three.
"I'm going to try and do more," said Benzema at the Marca awards ceremony. "That includes winning La Liga, scoring a lot of goals and most importantly, enjoying myself on the pitch."
1 - Barcelona have only conceded once in the top flight this season, with former Real Sociedad striker Alexander Isak netting in a 4-1 defeat, before his move to Newcastle United.
32 - The eastern city of Elche is known for its palm trees, and Edgar Badia's palms have certainly been busy this season. The Elche goalkeeper has made 32 saves, more than any of his counterparts, but in vain as his team sit bottom of the table.
100 - Real Madrid boast a 100 percent record this season across all competitions, with six wins from six in La Liga.
Fixtures (all times GMT)
Athletic Bilbao v Almeria (1900)
Cadiz v Villarreal (1200), Getafe v Real Valladolid (1415), Sevilla v Atletico Madrid (1630), Real Mallorca v Barcelona (1900)
Espanyol v Valencia (1200), Celta Vigo v Real Betis (1415), Girona v Real Sociedad (1630), Real Madrid v Osasuna (1900)
Rayo Vallecano v Elche (1900)